Centers of Excellence offer a broad range of facilities for the diagnosis, management, and treatment of patients with mastocytosis. The basis of such facilities is a local network of scientists and physicians who are already focusing their research and clinical work on mastocytosis. Centers of Excellence are referral centers that can be contacted from other hospitals or universities to get special information and advice concerning the diagnosis, management and therapy of patients with mastocytosis. Centers of Excellence can also be Reference Centers and Research Centers within the ECNM.